Co-Culture Assays for IO
LIDE’s co‑culture platforms allow researchers to model real-world tumor biology by combining multiple relevant cell types (e.g. tumor, stromal, and immune cells) within the same assay. By preserving cell–cell and cell–matrix interactions, these models deliver critical insights into immune evasion, therapeutic resistance, and immune-oncology drug responses in a controlled yet physiologically meaningful context.
| Feature | Benefit |
|---|---|
| Tumor–stromal co-culture | Combine cancer cells with fibroblasts or endothelial cells to model ECM and stromal interactions |
| Tumor–immune co-culture | Co-culture organoids or CR cells with PBMCs, TILs, NKs to assess immune engagement, cytotoxicity, and checkpoint responses |
| 3D organoid co-culture | Use PDX-derived organoids with matched immune cells for patient-specific IO testing |
| Multiplexed analysis | Bioluminescence, imaging cytometry, flow cytometry, and spatial analysis for readouts such as immune infiltration, proliferation, and cell death. |