LIDE has established 1600+ high quality PDX models in more than 40 cancer types – one of the largest coverage of any PDX bio bank in the world.
|Hepatocellular||96||HNC||6||Malignant pleural mesothel||2|
|Rectal||69||Mucinous carcinoma||5||Fallopian tube carcinoma||2|
Table: Summary of available PDX Models
Leverage our patient derived xenograft models and partner with LIDE on your next oncology research project:
- In vitro TCA compounds screening
- In vivo efficacy study
- Potential indication screening via MiniPDX assay
- Immunotherapy evaluation on huPBMC reconstituted models
Fig. Schematic of oncology R&D projects available through PDX models
Why LIDE Models:
- Many models of rare indications, drug resistant or relapsed/recurrent cancer
Because we have a MiniPDX® testing program with hospitals all over China, LIDE has been able to amass a large collection of rare 3R (resistant, relapsed, recurrent) models for testing of potential 2nd or 3rd line treatments.
- Highly-specific molecular targets and hard to find genetic alterations
LIDE has validated 200+ special drug resistant and/or genetic altered PDX models, including EGFR single/double/triple mutations in lung cancer, triple negative breast cancer, and models with KRAS mutation, HER2 amplification, or ALK/ROS1/NTRK fusion, etc.
Table: LIDE resistant and genetically modified PDX models
Cancer Type Resistant to Specific Genetic Alteration NSCLC Eriotinib
anti PD-L1 ab
EGFR: exon19del/T790M/L858R/exon20ins/ C797S
Breast Cancer CDK4/6i TNBC/ER+ Multiple Myeloma Bortezemonib CD47+/CD38+ Cholangiocarcinoma Paclitaxel KRAS: G12C
Colorectal Cancer Avastin KRAS: G12C
Hematological Malignancy Rituximab
/ Gastric Cancer Herceptin HER2: ampli
Brain Cancer / EGFR: VII
Melanoma anti PD-1 ab BRAF: V600E Ovarian Cancer Platinum
- Highest testing standards
Pathological analysis will be done using H&E staining from FFPE reserved during each passage of individual PDX models by a certified pathologist under the U.S. CAP standard. WES and RNAseq will be done in most of the established models according to the highest international standards of PDX Consortium.