Well Correlation Validated between MiniPDX and PDX

  • Fresh samples directly from patients were evaluated using MiniPDX, and demonstrated varied response to either biologic or small molecules (Left). Another aliquot of the same sample was utilized to establish conventional PDX model, while the treatments used in MiniPDX assay demonstrated the same results in such PDX in vivo efficacy studies (Right), which showed well correlation with MiniPDX.


Well correlation with MiniPDX

  • PDX models were established using fresh samples from patients, and showed varied response to S1, a pre-drug of the common chemotherapy. Using tumor tissues separate from such PDX model to do MiniPDX assay, in which the results showed well correlation between in vivo efficacy in PDX (Middle) and sensitivity in MiniPDX (Right).

    Well correlation between in vivo efficacy in PDX (Middle) and sensitivity in MiniPDX (Right)