Validation of CRCs Heterogeneity

  • Clients can perform primary screening for test articles using CRCs generated from established PDX models instead of genetic engineered cells or commercialized cancer cell lines. LIDE also launched internal validation to ensure the established CRCs demonstrate heterogeneity as its parental PDX tumors in case of sensitivity to indicated test articles.

A case of PDX matching Conditional reprogrammed cell lineA case of PDX matching Conditional reprogrammed cell line. A, AZD9291 inhibition curve of EGFR WT PDX derived cell line; B, AZD9291 inhibition curve EGFR L858R/T790M PDX derived cell line; C, AZD9291 inhibition curve of EGFR 19del/T790M /C797S PDX derived cell line; D; Morphology of EGFR 19del/T790M /C797S PDX derived cell line; Ki67 (E) and Pan-CK (F) staining of 19del/T790M /C797S PDX matching cell derived tumor sphere.