Application of MiniPDX in Drug R&D

Using either fresh tumor samples directly from patients or tumor tissues from established PDX models, potential clinical indications of specific investigated new drug can be determined via MiniPDX Mouse Trial.
RNA or DNA can be extracted and enriched from only thousands of cells left from MiniPDX preparation by K cell technology, while RNAseq can be further analyzed via functional genomic imaging (FGI). The Omics data would be useful for determination of potential bio-markers in order to distinguish responders/non-responders in population with certain indication(s) and further applied in patient stratification to confirm inclusive/exclusive criteria in clinical trials.

 

MiniPDX Mouse Trial